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Research

Folate

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By: Sean Moloughney

Editor, Nutraceuticals World

Indication: Hypertension

Source: JAMA, January 19, 2005;293:320-329.

Research: Investigators set out to determine if higher folate intake was associated with a lower risk of incident hypertension. To carry out their investigation, researchers examined two prospective cohort studies of 93,803 younger women aged 27 to 44 years in the Nurses’ Health Study II (1991-1999) and 62,260 older women aged 43 to 70 years in the Nurses’ Health Study I (1990-1998), who did not have a history of hypertension. Baseline information on dietary folate and supplemental folic acid intake was derived from semi-quantitative food frequency questionnaires and was updated every four years.

Results: Researchers found 7373 incident cases of hypertension in younger women and 12,347 cases in older women. After adjusting for multiple potential confounders, younger women who consumed at least 1000 micrograms a day of total folate (dietary plus supplemental) had a decreased risk of hypertension compared with those who consumed less than 200 micrograms per day. Among women who did not take folic acid-containing supplements, dietary folate intake of 400 micrograms per day or more was not significantly associated with the risk of hypertension. Higher total folate intake was associated with a decreased risk of incident hypertension, particularly in younger women.

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